All diseases start at the cell level, and some 200 diseases have one common cause: oxidative stress (cell damage by free radicals).  

And we know how to fix it: by activating Nrf2, which orders the body to stop the free radical damage and heal itself.   Read the studies and people's real experiences!

Injury or disease starts.

Oxidants destroy cells. You may be sick, weak, or feel pain.

Nrf2 is activated. 

The Nrf2 protein tells the DNA about the problems.  Nrf2 is a messenger.

DNA makes Antioxidants.

Antioxidants are sent to every cell of the body to fight any cell damage.

Antioxidants gobble up.

They destroy the oxidants at a rate of one million per second.

Your body heals.

You feel good again.


Nrf2 is a protein in your body that tells your body to create more protection for itself.  It is activated at the first signs of cell damage when illness or disease starts.  Since the first scientific article was written about the discovery of Nrf2 in October 1994, there are now about 8000 studies referencing Nrf2 and the positive effects it has on a multitude of various diseases. It has been the subject of various TV shows (Dr. Oz, Montel Williams, Healing Quest, etc.), and many companies are now producing and selling products that activate Nrf2 in the body, causing the body to heal itself from many diseases simultaneously.   The power of the body's own antioxidants have been found to be hundreds of times more effective than the antioxidant vitamins C and E.  Information about Nrf2 is slowly spreading. People who take supplements that activate Nrf2 find that the body will heal itself.  Scientists are discovering that the disease is not the problem - the real problem is with the pathways sending information within and between cells, which explains why people who get one problem tend to end up with many other problems too.  Studies have proven over and over that the right nutrition cures diseases and makes people live longer, healthier lives.  Learn more about your disease by reading the current research on, searching "oxidative stress", "(your disease)".  Summaries of some studies are included on each page of problems.


  •  NANCY had ADD, joint pain, skin cancer, and anxiety, but all got better after taking a Nrf2 activator.
  • TIM had aching joints, wrists, elbows, and knees, 4 ruptured discs, poor sleep, hours at a time in a fog, knuckles swollen and red, overweight, rough skin, age wrinkles, and an astigmatism.  After a Nrf2 activator all his conditions improved.
  •  DOROTHY had allergies and high cholesterol, but both got better after starting on a Nrf2 activator.
  • JIM had 37 different surgeries, cancer 3 times, fibromyalgia, kidney stones, issues with his pituitary, pancreas, gall bladder, and esophagus, his skin was jaundiced, and he was dying.  After taking a Nrf2 activator he improved, and went from 25 medications a day (costing copays of $380 a month) to only 7 pills (down to copays of only $25 a month).
  • JAN had Alzheimer’s Dementia with memory problems, and used a cane.  After being on a Nrf2 activator she has made real progress – all has gotten better.
  • DAVE had diabetes, taking 30 units of insulin a day, and 9 pain pills for his feet and leg pain.  But 2 months after starting Nrf2 activators, he only needs 12 units of insulin a day, and no longer needs any pain pills.
  • FRANK had bad luck starting with prostate cancer and moving to a ruptured appendix, heart attacks, leg muscle problems, colon cancer, diarrhea, joint problems, deteriorated back disc, clogged arteries, and heart failure.  Within 3 weeks of finally deciding to take a Nrf2 activator, he was completely off the steroids and codeine, and had no abdominal pain, no diarrhea and no chest pains.
  • ANDREA'S SON had been in speech therapy and behavior therapy for years for his autism, but after only 8 weeks of a Nrf2 activator his social progress skyrocketed.
  • Read more on the pages of this website for their complete stories and many other real-life examples of Nrf2 activation.


- ALL diseases begin at the cellular level.
- Free radicals (oxidants) have been found to be the cause of about 200 common diseases.
- Oxidants are also the consequence of many diseases, resulting in a continuous cycle of accumulation of more and more oxidants, causing more diseases and worsening conditions.
- Recent research directly links oxidants to hundreds of disease processes.
The type of disease one gets depends on the place where the oxidants are building up at and what cells are damaged.
- Knowing that oxidants are both the cause and consequence of diseases, current research suggests that many diseases can be treated simultaneously by simply activating the Nrf2 protein, causing the body to produce more of it's own natural antioxidants.


- It is a special messenger protein floating around in every cell of your body, informing your DNA of traumatic events happening in your body so that the DNA can make and send out defences.  

- It is kept inactive until the DNA needs to be informed that free radicals (oxidants) are destroying cells, such as in times of heavy workouts, sickness, exposure to toxins, and when diseases start.  Then your DNA produces antioxidants like Glutathione, Superoxide Dismutase, and Catalase to "gobble up" the problematic free radicals for the body to heal itself.

- It is abundant enough to prevent most problems when you are young, but after age 20 or so there are more free radicals than your body naturally can handle, so you start showing signs of aging and decline, and disease processes are more likely to begin.

Your natural antioxidant levels decrease 10-15% every 10 years, while free radicals increase in number, destroying cells and causing diseases.  This happens because Nrf2 is not activated as much.


- The future treatments for diseases is to get the body to heal itself by stimulating the body's own natural defence mechanisms.

- By treating the CAUSE of diseases (not just symptoms), people with multiple problems won't have to be on medications for each problem - one medicine to treat the common cause will be sufficient to fix all the problems at the same time.

- Nrf2 Activators activate thousands of beneficial genes (like immunity and balance of glucose) while simultaneously suppressing the expression of harmful genes (like inflammation).  

- Nrf2-activating Drugs have already been developed, such as Dimethyl Fumerate (a common brand is Tecfidera).  Drugs are intended to "treat" diseases.

- Herbal combinations have also been developed.  They have been studied for decades.  They often work better than drugs to activate Nrf2, with fewer or no side effects.  However, the FDA mandates that herbal remedies be labeled as "supplements," and may not be advertised as treatments even though they do the same thing as drugs do.


- Cancer spots have gone away, 

- Diabetes got under control, 

- Joint stiffness has relaxed, 

- Aches and pains and creaking sounds have gone away, 

- Night vision has gotten clearer, 

- Intestinal problems have cleared up, and 

- Mental acuity has improved.  


- Have energy to keep going on vigorous schedules, 

- Get more restful sleep, and 

- Have felt better than they have in years.  


- Can exercise longer periods of time, 

- Have faster recovery after exercise, 

- Don't get "sore" as much, and 

- Require less time between sets to get full power again.



- Most companies that make Nrf2 Activators are small, and have a limited advertising budget, so they don't have many ads.

- Some companies are internet-based, selling from their websites.  They do not have a physical location to go to, and maybe you have not come across it yet.

- Some other companies are network marketing companies, using independent distributors to spread the word.  Maybe nobody has contacted you yet.  

- Maybe your doctor has not learned about Nrf2 activators yet.  They have busy work and home lives, and may not spend extra time of research to learn about new treatments for the thousands of conditions that exist.  

- If a company is lucky, it may be featured on the news or investigative reports on TV, and you may have missed the episodes.

 Where to get
Grape Extract, Green Tea, L-Glutathione, N-Acetyl-L-Cysteine, R-Lipoic Acid
 Vitamin C, calcium, magnesium malates, wild blueberry, wild bilberry, acai, black currant, sweet cherry, raspberry, elderberry, blackberry, aronia, black soybean, blue corn, coffee berry, curcumin, trans-resveratrol, grape seed, cranberry, tart cherry, prune, raspberry seed, strawberry, quercetin, broccoli, broccoli sprouts, tomato, kale, carrot, brussels sprouts, onion, spinach, black pepper
Milk Thistle, Turmeric, Ashwagandha, Bacopa, Green Tea
 Sulforaphane, Black Pepper, Turmeric, Green Tea, Pterostilbene, Bacopa
  Ultimate Nrf2 Stimulator
 Broccoli Seed, Turmeric Rhizome, Green Tea, Pterostilbene, Black Pepper
 NAS Enhancer
 Turmeric, Green Tea, Trans-pterostilbene, Broccoli, Black Pepper
 Glucoraphanin, Turmeric, Green Tea, trans-Pterostilbene, Black pepper
 Nrf2 Boost
  Broccoli seed, Turmeric, Green Tea, Trans-pterostilbene, Black Pepper
Nrf2 Renew, 
Green Tea, Milk thistle, Pomegranite, Green Coffee PE, Gingko, Olive Leaf, Aulforaphane, L-leucine
 Nrf2 Rising
Green Tea, Milk thistle, Pomegranite, Green Coffee PE, Gingko, Olive Leaf, Aulforaphane, L-leucine

Astaxanthin, turmeric, pressed kiwifruit seed oil, flax seed oil, pine bark extract, grape seed extract, grape skin extract, kiwifruit extract, boysenberry extract, blackcurrant extract, black pepper extract
 Redox Signaling molecules (liquid form)
 Nrf2 Support
Turmeric, Green Tea, Trans-pterostilbene, Broccoli, Black Pepper
RiboCeine, Alpha Lipoic Acid, Broccoli Seed, Turmeric, Resveratrol, Grape Seed, Quercetin, Milk Thistle, Vitamin C, Selenomethionine, Cordyceps, Black Pepper, Aloe
 Muscadine grape, European Elderberry, Purple carrot, trans-resveratrol
 $40., 50 mg
 $45., 50 mg
 $59., 50 mg
 $89., 50 mg
 $169., 10 mg
 $178., 10 mg
 $315., 50 mg
 TAT 14
$155., 1 mg
The body is designed to heal itself, but it sometimes needs help from a doctor or dietary supplements.

Ultimate Protector has the lowest price for the most Nrf2 Activator ingredients.  Go to their website.


Oxidative stress is caused by toxins (smoking, alcohol, chemical exposure, air pollution, etc.), tissue injury (cuts, breaks, etc.), too much or too little exercise, excess life stress, ionizing radiation (x-rays, sun, cellphones), fungal toxins (mold), chronic infections, and lack of sleep.


Nrf2 activators can be found in foods and herbs. Foods that stimulate Nrf2 include fruits (apples, bananas, etc.), vegetables (broccoli, celery, etc.), other foods with polyphenols (olives, olive oil, nuts, citrus fruits, cereals, legumes), tocopherols (wheat germ oil, lettuce, spinach, egg yolk), tocotrienols (vegetable oils, wheat germ), carotenoids (carrots, apricots), isothiocyanates (mustard, wasabi, horseradish, Brussels sprouts, watercress), allium vegetables (onion, garlic, chives, leek), and terpenoids (Ginkgo Biloba, turmeric, cinnamon, ginger, and tomatoes). See the list of fruits and vegetables and what conditions they are good for.

Nrf2-activating herb combinations that have been created by some supplement companies include Ultimate Protector, ProtandimNrf-2 OptimizerGENIE Nrf2 StimulatorNrf2 ActivatorAntioxidant BlackASEANrf2 AdvantageNrf2ActivateCellgevity, and Vivix.  The herb combination that has been studied the most is Protandim.

Here is a small selection of common conditions and diseases that Nrf2 Activators can help with, since they all share the same common cause: Oxidative Stress (cell damage by oxidants).


Alimentary Canal Diseases


Alzheimer's Disease






Attention Deficit Disorder (ADD)

Bronchitis (chronic)


Chronic Obstructive Pulmonary Disease (COPD)

Congestive Heart Failure (CHF)

Connective Tissue Damage
Diabetes (DM)
Down Syndrome
Equilibrium Disorders
Halitosis (bad breath)
Hypertension (HTN, high blood pressure)
High cholesterol
Immune system disorders
Macular Degeneration
Multiple Sclerosis (MS)
Muscle energy loss
Parkinson's Disease
Sore gums
Sore throat
Vision Loss (age-related)


Indian J Clin Biochem. 2015 Jan;30(1):11-26. doi: 10.1007/s12291-014-0446-0. Epub 2014 Jul 15.

Free radicals: properties, sources, targets, and their implication in various diseases.

Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals, industrial solvents, pesticides, certain drugs like halothane, paracetamol, and radiation). Free radicals can adversely affect various important classes of biological molecules such as nucleic acids, lipids, and proteins, thereby altering the normal redox status leading to increased oxidative stress. The free radicals induced oxidative stress has been reported to be involved in several diseased conditions such as diabetes mellitus, neurodegenerative disorders (Parkinson's disease-PD, Alzheimer's disease-AD and Multiple sclerosis-MS), cardiovascular diseases (atherosclerosis and hypertension), respiratory diseases (asthma), cataract development, rheumatoid arthritis and in various cancers (colorectal, prostate, breast, lung, bladder cancers). This review deals with chemistry, formation and sources, and molecular targets of free radicals and it provides a brief overview on the pathogenesis of various diseased conditions caused by ROS/RNS.

[INTERPRETATION:  free radicals and other oxidants play a central role in diseases by causing oxidative stress (cell damage), resulting in many different diseases, including diabetes, Parkinson’s, Alzheimer’s, MS, atherosclerosis, hypertension, asthma, cataracts, arthritis, and cancer.]


 Sheng Li Xue Bao. 2015 Feb 25;67(1):1-18.

 Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors.

 The transcription factor Nrf2, nuclear factor erythroid-2-related factor 2, activates the transcription of over 500 genes in the human genome, most of which have cytoprotective functions. Nrf2 produces cytoprotection by detoxification mechanisms leading to increased detoxification and excretion of both organic xenobiotics and toxic metals; its action via over two dozen genes increases highly coordinated antioxidant activities; it produces major anti-inflammatory changes; it stimulates mitochondrial biogenesis and otherwise improves mitochondrial function; and it stimulates autophagy, removing toxic protein aggregates and dysfunctional organelles. Health-promoting nutrients and other factors act, at least in part by raising Nrf2 including: many phenolic antioxidants; gamma- and delta-tocopherols and tocotrienols; long chain omega-3 fatty acids DHA and EPA; many carotenoids of which lycopene may be the most active; isothiocyanates from cruciferous vegetables; sulfur compounds from allium vegetables; terpenoids. Other health promoting, Nrf2 raising factors include low level oxidative stress (hormesis), exercise and caloric restriction. Raising Nrf2 has been found to prevent and/or treat a large number of chronic inflammatory diseases in animal models and/or humans including various cardiovascular diseases, kidney diseases, lung diseases, diseases of toxic liver damage, cancer (prevention), diabetes/metabolic syndrome/obesity, sepsis, autoimmune diseases, inflammatory bowel disease, HIV/AIDS and epilepsy. Lesser evidence suggests that raising Nrf2 may lower 16 other diseases. Many of these diseases are probable NO/ONOO(-) cycle diseases and Nrf2 lowers effects of NO/ONOO(-) cycle elements. The most healthful diets known, traditional Mediterranean and Okinawan, are rich in Nrf2 raising nutrients as apparently was the Paleolithic diet that our ancestors ate. Modern diets are deficient in such nutrients. Nrf2 is argued to be both lifespan and healthspan extending. Possible downsides to too much Nrf2 are also discussed. Nrf2 is not a magic bullet but is likely to be of great importance in health promotion, particularly in those regularly exposed to toxic chemicals.

 PMID:  25672622  

 [INTERPRETATION:  Nrf2 protects cells by methods of detoxification, reduction of inflammation, improvement of cell energy, and many other ways.  Increasing Nrf2 prevents and treats many different diseases at the same time, and increases lifespan.]

Think this science is all FAKE?  BALONEY?  See Tools for Skeptical Thinking.