Glutathione deserves special consideration, since Nrf2 activators cause it to be produced.  Here are some things that could happen if you have low levels of it in your body:

GENERAL: Obesity, Immune signaling, Endothelial dysfunction, Alcoholism, Inflammation, Heavy metal poisoning

CARDIOVASCULAR: Angina and spastic angina, Unstable angina, Heart attacks, Positive stress tests, Reperfusion after cardiac bypass surgery

PULMONARY: Emphysema (COPD), Pulmonary Fibrosis (IPF), Asthma, Muscle wasting in COPD, Chronic bronchitis, Tobacco abuse

OPTHAMOLOGY: Cataracts, Macular Degeneration

RHEUMATOLOGY: Systemic Lupus Erythematosus, Rheumatoid arthritis, Multiple Sclerosis (MS), Systemic Sclerosis, Scleroderma Syndrome, Behcet’s Syndrome, ME/CFS, Fibromyalgia & Others

NEURO/PSYCH: Migraine headaches, Alzheimer’s, Parkinson’s, Multi infarct dementia, Autism, ADHD (Attention Deficit Hyperactivity Disorder), Bipolar disease, Schizophrenia, Lou Gehrig’s disease, Huntington’s chorea, Multiple Sclerosis (MS), Depression

DERMATOLOGY: Wrinkles, sagging, Acne, Psoriasis, Atopic dermatitis, Eczema & Others

INFECTIOUS DISEASE/IMMUNOLOGY: Hepatitis A, B, and C; Herpes simplex; Herpes zoster/shingles; Influenza and Bird Flu; HIV; MRSA; Common viral infections (upper respiratory, gastroenteritis) & Others

ONCOLOGY: Every cancer studied including: Brain, Head and neck, Thyroid, Lung, Esophagus, Stomach; Intestine, Liver, Pancreas, Kidney, Uterine, Ovarian, Prostate, Leukemia (acute and chronic), Lymphoma, Multiple myeloma & Others

OB/GYN: Infertility, Spontaneous abortions, Pre Menstrual Syndrome

(Excerpt from: GLUTATHIONE Your Best Defense Against Aging, Cellular Damage and Disease by Dr Robert H. Keller, MD, Director of Medicine & Research/KBK Institute of Advanced Medicine, Published 2008)